Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases
نویسندگان
چکیده
منابع مشابه
Intramembrane cleaving proteases (I-CLiPs) as guardians of shuttling proteins
The concept of proteases cleaving their substrates within the hydrophobic core of their transmembrane domains is very well established. in the past 15 years, various intramembrane cleaving proteases (i-CliPs) and their respective substrates have been identified.1 Besides the involvement in specific signaling pathways, for instance regulation of cholesterol metabolism or Notch signaling,1 a prot...
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Neuregulin-1 Type III Determines the Ensheathment Fate of Axons
The signals that determine whether axons are ensheathed or myelinated by Schwann cells have long been elusive. We now report that threshold levels of neuregulin-1 (NRG1) type III on axons determine their ensheathment fate. Ensheathed axons express low levels whereas myelinated fibers express high levels of NRG1 type III. Sensory neurons from NRG1 type III deficient mice are poorly ensheathed an...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2016
ISSN: 0021-9258
DOI: 10.1074/jbc.m115.697995